About   Help   FAQ
Smad3tm1Par
Targeted Allele Detail
Nomenclature
Symbol: Smad3tm1Par
Name: SMAD family member 3; targeted mutation 1, Luis F Parada
MGI ID: MGI:1857592
Synonyms: Madh3-, Smad3-, Smad3tm1par-
Gene: Smad3  Location: Chr9:63646767-63757994 bp, - strand  Genetic Position: Chr9, 34.22 cM, cytoband D
Colon tumor formation and neoplasia in Rab25tm1Jrgo/Rab25tm1Jrgo Smad3tm1Par/Smad3+ mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:49839
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
 
Mutation detailsAn IRES-LacZ-neo cassette was inserted into exon 2 of the gene, truncating the carboxyl-terminal active domain of the protein. In addition, this cassette was inserted in a region where point mutations create loss-of-function proteins. Finally, alternative splicing around the disrupted exon would shift the open reading frame. (J:49839)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 16 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Smad3 Mutation:  2 strains or lines available
References
Original:  J:49839 Zhu Y, et al., Smad3 mutant mice develop metastatic colorectal cancer. Cell. 1998 Sep 18;94(6):703-14
All:  30 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2015
MGI 5.21
The Jackson Laboratory