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Trp53tm1Brd
Targeted Allele Detail
Summary
Symbol: Trp53tm1Brd
Name: transformation related protein 53; targeted mutation 1, Allan Bradley
MGI ID: MGI:1857590
Synonyms: P-, p53-, p53N, Trp53-, Trp53delta, Trp53N, TSG-p53
Gene: Trp53  Location: Chr11:69471185-69482699 bp, + strand  Genetic Position: Chr11, 42.83 cM, cytoband B2-C
Alliance: Trp53tm1Brd page
Tumor multiplicity and proliferation index in Cdkn2atm1Cjs/Cdkn2atm1Cjs, Trp53tm1Brd/Trp53tm1Brd and Cdkn2atm1Cjs/Cdkn2atm1Cjs Trp53tm1Brd/Trp53tm1Brd mice

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:1999
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt1+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PolII-neomycin resistance cassette which lacked a polyadenylation signal was inserted into exon 5 of the gene. The insertion was accompanied by a small deletion of a 450 bp fragment containing 106 nucleotides of exon 5 and 350 nucleotides of intron 4. (J:1999, J:96886)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 73 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 6 anatomical structure(s)
Tumor Data
List all tumor models in MMHCdb carrying Trp53tm1Brd
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Carrying any Trp53 Mutation:  232 strains or lines available
References
Original:  J:1999 Donehower LA, et al., Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature. 1992 Mar 19;356(6366):215-21
All:  584 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory