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Rad51tm1Hst
Targeted Allele Detail
Nomenclature
Symbol: Rad51tm1Hst
Name: RAD51 recombinase; targeted mutation 1, Paul Hasty
MGI ID: MGI:1857587
Synonyms: rad51m1-
Gene: Rad51  Location: Chr2:119112793-119147445 bp, + strand  Genetic Position: Chr2, 59.92 cM, cytoband F1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:36540
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA puromycin selection cassette replaced the region encoding amino acids 73 through 112 and caused a downstream frameshift mutation. RT-PCR analysis of mRNA isolated from homozygous mutant embryos revealed the exclusive presence of a truncated transcript. (J:36540)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 2 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rad51 Mutation:  18 strains or lines available
References
Original:  J:36540 Lim DS, et al., A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol. 1996 Dec;16(12):7133-43
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory