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Runx1tm1Dow
Targeted Allele Detail
Nomenclature
Symbol: Runx1tm1Dow
Name: runt related transcription factor 1; targeted mutation 1, James R Downing
MGI ID: MGI:1857580
Synonyms: AML-, AML1-, Runx1-
Gene: Runx1  Location: Chr16:92601466-92826149 bp, - strand  Genetic Position: Chr16, 53.7 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31130
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA hygromycin B expression cassette replaced the splice acceptor site and the first 20 bp of the exon that encodes the central 52 amino acids of the Runt homology domain (RHD). RT-PCR analysis on RNA derived from whole E11.5 embryos did not detect any transcript in homozygous mice. (J:31130)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 4 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx1 Mutation:  18 strains or lines available
References
Original:  J:31130 Okuda T, et al., AML1, the target of multiple chromosomal translocations in human leukemia, is essential for normal fetal liver hematopoiesis. Cell. 1996 Jan 26;84(2):321-30
All:  10 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory