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Targeted Allele Detail
Symbol: Eportm1Cos
Name: erythropoietin receptor; targeted mutation 1, Frank Costantini
MGI ID: MGI:1857575
Gene: Epor  Location: Chr9:21958897-21963506 bp, - strand  Genetic Position: Chr9, 7.93 cM
Germline Transmission:  Earliest citation of germline transmission: J:31156
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing 6 of the 8 exons of the gene was replaced by a neomycin resistance cassette. (J:31156)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 19 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epor Mutation:  12 strains or lines available
Since homozygotes die by E13.5, chimeras, in which homozygous mutant ES cells were injected into wild-type embryos, were used to analyze hematopoiesis in adults. Homozygous mutant cells fail to contribute to the red blood cell fraction of chimeric adults although they contribute extensively to the white cell fraction (J:31156).
Original:  J:31156 Lin CS, et al., Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996 Jan 15;10(2):154-64
All:  5 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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