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Eportm1Cos
Targeted Allele Detail
Nomenclature
Symbol: Eportm1Cos
Name: erythropoietin receptor; targeted mutation 1, Frank Costantini
MGI ID: MGI:1857575
Gene: Epor  Location: Chr9:21958899-21963576 bp, - strand  Genetic Position: Chr9, 7.93 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:31156
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 19 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Epor Mutation:  4 strains or lines available
Notes
Since homozygotes die by E13.5, chimeras, in which homozygous mutant ES cells were injected into wild-type embryos, were used to analyze hematopoiesis in adults. Homozygous mutant cells fail to contribute to the red blood cell fraction of chimeric adults although they contribute extensively to the white cell fraction (J:31156).

References
Original:  J:31156 Lin CS, et al., Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis. Genes Dev. 1996 Jan 15;10(2):154-64
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory