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Targeted Allele Detail
Symbol: Tal1tm1Wehi
Name: T cell acute lymphocytic leukemia 1; targeted mutation 1, Walter and Eliza Hall Institute of Medical Research
MGI ID: MGI:1857566
Synonyms: scl-
Gene: Tal1  Location: Chr4:115056426-115071755 bp, + strand  Genetic Position: Chr4, 52.73 cM
Appearance and histology of Tal1tm1Wehi/Tal1tm1Wehi embryos

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:27458
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsTwo targeting vectors were used to create two targeted mutations, but these were not distinguished in the paper. Vector 582 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a neomycin gene. Vector 607 disrupted the Tal1 gene by replacing the sequences encoding the b-HLH domain with a hygromycin gene. (J:27458)
Inheritance:    Recessive
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 34 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tal1 Mutation:  20 strains or lines available
Original:  J:27458 Robb L, et al., Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene. Proc Natl Acad Sci U S A. 1995 Jul 18;92(15):7075-9
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
The Jackson Laboratory