About   Help   FAQ
Pkd1tm1Jzh
Targeted Allele Detail
Summary
Symbol: Pkd1tm1Jzh
Name: polycystin 1, transient receptor potential channel interacting; targeted mutation 1, Jing Zhou
MGI ID: MGI:1857562
Synonyms: del34, Pkd1-, Pkd1del34
Gene: Pkd1  Location: Chr17:24768808-24815482 bp, + strand  Genetic Position: Chr17, 12.4 cM
Alliance: Pkd1tm1Jzh page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:43193
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 34 was replaced with a neomycin cassette, resulting in expression of a truncated protein. This mutation mimics a known mutation in humans. (J:43193)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Loading...
Expression
In Mice Carrying this Mutation: 16 assay results
1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 21 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pkd1 Mutation:  153 strains or lines available
References
Original:  J:43193 Lu W, et al., Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet. 1997 Oct;17(2):179-81
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory