Pax1^tm1Neu
Targeted Allele Detail

Summary

• Symbol: Pax1^tm1Neu
• Name: paired box 1; targeted mutation 1, Neuherberg
• MGI ID: MGI:1857560
• Synonyms: Pax1^null
• Gene: Pax1 Location: Chr2:147203850-147216972 bp, + strand Genetic Position: Chr2, 72.63 cM
• Alliance: Pax1^tm1Neu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:49339
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK-neomycin based targeting vector replaced the 5' region of the gene including exons 1 and 2. Western analysis on homozygous mutant embryos demonstrated an absence of wild-type protein. (J:49339)

Expression

In Mice Carrying this Mutation:	46 assay results
In Structures Affected by this Mutation:	15 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pax1 Mutation: 28 strains or lines available

References

• Original: J:49339 Wilm B, et al., Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency. Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8692-7
• All: 6 reference(s)