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Alx1tm1Crm
Targeted Allele Detail
Nomenclature
Symbol: Alx1tm1Crm
Name: ALX homeobox 1; targeted mutation 1, Benoit de Crombrugghe
MGI ID: MGI:1857553
Synonyms: Cart1-
Gene: Alx1  Location: Chr10:103007846-103029054 bp, - strand  Genetic Position: Chr10, 53.56 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33716
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced a 7.4kb genomic fragment containing exons 1-3. These sequences encode two thirds of the protein including the homeodomain and the potential translation initiation site. (J:33716)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Alx1 Mutation:  8 strains or lines available
References
Original:  J:33716 Zhao Q, et al., Prenatal folic acid treatment suppresses acrania and meroanencephaly in mice mutant for the Cart1 homeobox gene. Nat Genet. 1996 Jul;13(3):275-83
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory