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Gli2tm1Alj
Targeted Allele Detail
Nomenclature
Symbol: Gli2tm1Alj
Name: GLI-Kruppel family member GLI2; targeted mutation 1, Alexandra L Joyner
MGI ID: MGI:1857509
Synonyms: Gli2-, Gli2zfd
Gene: Gli2  Location: Chr1:118834132-119053619 bp, - strand  Genetic Position: Chr1, 52.17 cM, cytoband E2-E4
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38381
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced 2.4 kb of the gene, resulting in the deletion of exons that encode the zinc fingers 3 - 5 of the protein and 71 amino acid residues carboxyl to these zinc fingers. (J:38381, J:49164)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 357 assay results
In Structures Affected by this Mutation: 53 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gli2 Mutation:  92 strains or lines available
References
Original:  J:38381 Mo R, et al., Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development. Development. 1997 Jan;124(1):113-23
All:  104 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/05/2019
MGI 6.14
The Jackson Laboratory