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Otx2tm1Sla
Targeted Allele Detail
Summary
Symbol: Otx2tm1Sla
Name: orthodenticle homeobox 2; targeted mutation 1, Siew Lan Ang
MGI ID: MGI:1857502
Synonyms: Otx2-, Otx2hd, Otx2neo
Gene: Otx2  Location: Chr14:48894238-48905101 bp, - strand  Genetic Position: Chr14, 25.36 cM
Alliance: Otx2tm1Sla page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30828
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced the sequences encoding the homeodomain. This mutation is predicted to truncate the Otx2 coding sequence immediately after the first 32 amino acids. (J:30828)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 71 assay results
In Structures Affected by this Mutation: 9 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Otx2 Mutation:  50 strains or lines available
References
Original:  J:30828 Ang SL, et al., A targeted mouse Otx2 mutation leads to severe defects in gastrulation and formation of axial mesoderm and to deletion of rostral brain. Development. 1996 Jan;122(1):243-52
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory