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Targeted Allele Detail
Symbol: Cyp2e1tm1Gonz
Name: cytochrome P450, family 2, subfamily e, polypeptide 1; targeted mutation 1, Frank J Gonzalez
MGI ID: MGI:1857483
Synonyms: Cyp2e1-
Gene: Cyp2e1  Location: Chr7:140343732-140354903 bp, + strand  Genetic Position: Chr7, 85.94 cM
Germline Transmission:  Earliest citation of germline transmission: J:48196
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a neomycin resistance cassette. Northern blot analysis demonstrated that the normal transcript was not present in liver of homozygous mice. Western blot analysis confirmed the absence of the protein in liver extracts derived from homozygous mice. (J:48196)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cyp2e1 Mutation:  24 strains or lines available
Original:  J:48196 Lee SS, et al., Role of CYP2E1 in the hepatotoxicity of acetaminophen. J Biol Chem. 1996 May 17;271(20):12063-7
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory