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Pomctm1Low
Targeted Allele Detail
Nomenclature
Symbol: Pomctm1Low
Name: pro-opiomelanocortin-alpha; targeted mutation 1, Malcolm J Low
MGI ID: MGI:1857481
Synonyms: betaend-, beta-END-, End-, POMCX*4-
Gene: Pomc  Location: Chr12:3954951-3960618 bp, + strand  Genetic Position: Chr12, 1.99 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:47711
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Pomc Mutation:  8 strains or lines available
Notes
Additional reference J:65685 identifies the ES cell line origin as 129S2/SvEv. It is more likely that the mice used in this additional reference were derived from the targeted D3 ES cells (129S2/SvPas) first generated in J:78759 and implanted in mice in J:47711.

References
Original:  J:47711 Rubinstein M, et al., Absence of opioid stress-induced analgesia in mice lacking beta-endorphin by site-directed mutagenesis. Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):3995-4000
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory