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Targeted Allele Detail
Symbol: Ascl1tm1And
Name: achaete-scute family bHLH transcription factor 1; targeted mutation 1, David J Anderson
MGI ID: MGI:1857470
Synonyms: Ascl1delta, Mash-1-, Mash1-, Mash-1delta
Gene: Ascl1  Location: Chr10:87326681-87329522 bp, - strand  Genetic Position: Chr10, 43.64 cM
Germline Transmission:  Earliest citation of germline transmission: J:15850
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  129/Sv
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA PGK-neomycin resistance cassette replaced the entire coding region, 0.6 kb of sequence 5' of the translation initiation codon, and 0.2 kb of sequence 3' of the translation termination codon. (J:15850)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 358 assay results
In Structures Affected by this Mutation: 7 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ascl1 Mutation:  23 strains or lines available
ES cell line = D3 (129S2/SvPas) or R1 (129S1/Sv x 129X1/SvJ)F1. The authors state that most phenotypic analysis was done on R1-derived mice.
Original:  J:15850 Guillemot F, et al., Mammalian achaete-scute homolog 1 is required for the early development of olfactory and autonomic neurons. Cell. 1993 Nov 5;75(3):463-76
All:  111 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory