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Targeted Allele Detail
Symbol: Igf1tm1Ts
Name: insulin-like growth factor 1; targeted mutation 1, Timothy Stewart
MGI ID: MGI:1857466
Synonyms: IGF-I-
Gene: Igf1  Location: Chr10:87858265-87937042 bp, + strand  Genetic Position: Chr10, 43.7 cM
Germline Transmission:  Earliest citation of germline transmission: J:16214
Parent Cell Line:  AB1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprt+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 3 after codon 15. This mutation inserts multiple stop codons into all reading frames of the B chain of the encoded protein. RT-PCR analysis demonstrated that the transcript is undetectable in homozygous animals. (J:16214)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igf1 Mutation:  16 strains or lines available
Original:  J:16214 Powell-Braxton L, et al., IGF-I is required for normal embryonic growth in mice. Genes Dev. 1993 Dec;7(12B):2609-17
All:  29 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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