Mecom^tm1Mmor
Targeted Allele Detail

Summary

• Symbol: Mecom^tm1Mmor
• Name: MDS1 and EVI1 complex locus; targeted mutation 1, Michael L Mucenski
• MGI ID: MGI:1857461
• Synonyms: Evi1
• Gene: Mecom Location: Chr3:30005445-30563937 bp, - strand Genetic Position: Chr3, 12.66 cM
• Alliance: Mecom^tm1Mmor page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42030
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 6 at nucleotide 1304. RT-PCR analysis on RNA derived from E10.5 embryos demonstrated that the expression of a full length transcript was eliminated in homozygous embryos, but the expression of a shorter transcript (called delta324 by the authors) was unaffected. (J:42030)

Expression

In Mice Carrying this Mutation:	20 assay results
In Structures Affected by this Mutation:	22 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mecom Mutation: 81 strains or lines available

References

• Original: J:42030 Hoyt PR, et al., The Evi1 proto-oncogene is required at midgestation for neural, heart, and paraxial mesenchyme development. Mech Dev. 1997 Jul;65(1-2):55-70
• All: 6 reference(s)