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Targeted Allele Detail
Symbol: Ciitatm1Ccum
Name: class II transactivator; targeted mutation 1, Cheong-Hee Chang
MGI ID: MGI:1857456
Synonyms: C2tatm1Ccum, CIITA-, CIITA C-, MHC classII-
Gene: Ciita  Location: Chr16:10488178-10527564 bp, + strand  Genetic Position: Chr16, 5.65 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:31601
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA genomic fragment containing exons which encode critical regions of the protein was replaced with a neomycin selection gene. Northern blot analysis on RNA derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:31601)
View phenotypes for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Ciita Mutation:  6 strains or lines available
Original:  J:31601 Chang CH, et al., Mice lacking the MHC class II transactivator (CIITA) show tissue-specific impairment of MHC class II expression. Immunity. 1996 Feb;4(2):167-78
All:  51 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 5.21
The Jackson Laboratory