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Vcam1tm1Roml
Targeted Allele Detail
Nomenclature
Symbol: Vcam1tm1Roml
Name: vascular cell adhesion molecule 1; targeted mutation 1, Mark A Labow
MGI ID: MGI:1857452
Synonyms: VCAM-1 -
Gene: Vcam1  Location: Chr3:116109949-116129688 bp, - strand  Genetic Position: Chr3, 50.17 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23137
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin resistance expression cassette replaced a genomic fragment containing part of exon 2 and exons 3-5. These sequences encode the Ig domains. (J:23137)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 10 assay results
In Structures Affected by this Mutation: 8 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vcam1 Mutation:  25 strains or lines available
References
Original:  J:23137 Kwee L, et al., Defective development of the embryonic and extraembryonic circulatory systems in vascular cell adhesion molecule (VCAM-1) deficient mice. Development. 1995 Feb;121(2):489-503
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory