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Sp4tm1Ssp
Targeted Allele Detail
Nomenclature
Symbol: Sp4tm1Ssp
Name: trans-acting transcription factor 4; targeted mutation 1, S Steven Potter
MGI ID: MGI:1857451
Gene: Sp4  Location: Chr12:118234933-118301440 bp, - strand  Genetic Position: Chr12, 63.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33573
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence encoding three zinc-finger domains was replaced with a construct containing an HPRT gene. Northern blot analysis of brain extracts showed the presence of an aberrant transcript in homozygous mutant mice. The transcript was undetectable in further analysis using a probe specific for the zinc-finger domains. (J:33573)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sp4 Mutation:  15 strains or lines available
References
Original:  J:33573 Supp DM, et al., Sp4, a member of the Sp1-family of zinc finger transcription factors, is required for normal murine growth, viability, and male fertility. Dev Biol. 1996 Jun 15;176(2):284-99
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory