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Targeted Allele Detail
Symbol: Rbl2tm1Tyj
Name: RB transcriptional corepressor like 2; targeted mutation 1, Tyler Jacks
MGI ID: MGI:1857449
Synonyms: p130-
Gene: Rbl2  Location: Chr8:91796685-91850472 bp, + strand  Genetic Position: Chr8, 44.25 cM
Germline Transmission:  Earliest citation of germline transmission: J:34725
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced sequences in a proximal exon of the Rbl2 gene. Rbl2 mRNA levels in liver cells of homozygous mutant animals were reduced more than five fold compared to wild-type. Immunoblot analysis did not detect RBL2 protein in embryonic fibroblasts or in adult liver of homozygous mutant mice. (J:34725)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 126 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rbl2 Mutation:  35 strains or lines available
Original:  J:34725 Cobrinik D, et al., Shared role of the pRB-related p130 and p107 proteins in limb development. Genes Dev. 1996 Jul 1;10(13):1633-44
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory