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Rbl1tm1Tyj
Targeted Allele Detail
Nomenclature
Symbol: Rbl1tm1Tyj
Name: retinoblastoma-like 1 (p107); targeted mutation 1, Tyler Jacks
MGI ID: MGI:1857448
Synonyms: p107-
Gene: Rbl1  Location: Chr2:157145893-157204534 bp, - strand  Genetic Position: Chr2, 78.05 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34058
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA PGK-neomycin cassette replaced sequences in exon 1 and a downstream intron of the Rbl1 gene. The authors predict that the mutant allele will synthesize only the first 22 amino acids of the wild-type protein. RBL1 protein was not detected in embryonic fibroblasts derived from homozygous mutant mice, or in homozygous mutant E18 embryos. Rbl1 transcript was not detected in homozygous mutant E18 embryos. (J:34058)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 160 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rbl1 Mutation:  11 strains or lines available
References
Original:  J:34058 Lee MH, et al., Targeted disruption of p107: functional overlap between p107 and Rb. Genes Dev. 1996 Jul 1;10(13):1621-32
All:  49 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory