About   Help   FAQ
Targeted Allele Detail
Symbol: Ptch1tm1Mps
Name: patched homolog 1; targeted mutation 1, Matthew P Scott
MGI ID: MGI:1857447
Synonyms: LacZ/Ptc, ptc-, Ptc1-, Ptc1-lacZ, Ptc1lzki, Ptch-, Ptch1-, Ptch1-lacZ, PtchKO1, PtchlacZ, ptc-lacZ, PtclacZ, Ptcn
Gene: Ptch1  Location: Chr13:63508328-63573598 bp, - strand  Genetic Position: Chr13, 32.8 cM
Germline Transmission:  Earliest citation of germline transmission: J:42441
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA construct containing a promoterless lacZ-neo fusion gene was inserted at the start codon and deleted a portion of exon 1 and all of exon 2, which encoded the first transmembrane domain. Expression of the inserted lacZ gene served as an accurate reporter in heterozygotes but was found to be derepressed in homozygous mutant mice. (J:42441)
View phenotypes for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 195 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ptch1 Mutation:  21 strains or lines available
Original:  J:42441 Goodrich LV, et al., Altered neural cell fates and medulloblastoma in mouse patched mutants. Science. 1997 Aug 22;277(5329):1109-13
All:  215 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
MGI 6.0
The Jackson Laboratory