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Plp1tm1Kan
Targeted Allele Detail
Summary
Symbol: Plp1tm1Kan
Name: proteolipid protein (myelin) 1; targeted mutation 1, Klaus-Armin Nave
MGI ID: MGI:1857446
Synonyms: Plp-, PLP/DM20 null, PLP-null
Gene: Plp1  Location: ChrX:135723420-135740482 bp, + strand  Genetic Position: ChrX, 59.1 cM, cytoband F1-F2
Alliance: Plp1tm1Kan page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:38856
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette introduced by homologous recombination replaced the 3' part of exon 1,including the translation start codon and a 2.5 kb fragment of the first intron of Plp ("PLP/DM20 gene"). Western blot analysis showed absence of both PLP and DM20 proteolipids proteins in hemizygous mutant mice. (J:38856)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Plp1 Mutation:  20 strains or lines available
References
Original:  J:38856 Klugmann M, et al., Assembly of CNS myelin in the absence of proteolipid protein. Neuron. 1997 Jan;18(1):59-70
All:  33 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory