Col4a3^tm1Dec
Targeted Allele Detail

Nomenclature

• Symbol: Col4a3^tm1Dec
• Name: collagen, type IV, alpha 3; targeted mutation 1, Dominic Cosgrove
• MGI ID: MGI:1857432
• Gene: Col4a3 Location: Chr1:82564642-82699780 bp, + strand Genetic Position: Chr1, 42.32 cM

Sostdc1^tm1Myan/Sostdc1^tm1Myan Col4a3^tm1Dec/Col4a3^tm1Dec mice show less glomerular and tubular injury than Col4a3^tm1Dec/Col4a3^tm1Dec mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37963
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin selection cassette was inserted into exon 5. Northern blot analysis on RNA derived from kidney of homozygous mice demonstrated that no detectable transcript is produced from this allele. Immunohistochemistry experiments on kidney sections from homozygous mice confirmed that no detectable protein is made. (J:37963)

Disease models

Expression

In Structures Affected by this Mutation:

15 anatomical structures

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Col4a3 Mutation: 46 strains or lines available

References

• Original: J:37963 Cosgrove D, et al., Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev. 1996 Dec 1;10(23):2981-92
• All: 61 reference(s)