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Targeted Allele Detail
Symbol: Col4a3tm1Dec
Name: collagen, type IV, alpha 3; targeted mutation 1, Dominic Cosgrove
MGI ID: MGI:1857432
Gene: Col4a3  Location: Chr1:82586921-82722059 bp, + strand  Genetic Position: Chr1, 42.32 cM
Sostdc1tm1Myan/Sostdc1tm1Myan Col4a3tm1Dec/Col4a3tm1Dec mice show less glomerular and tubular injury than Col4a3tm1Dec/Col4a3tm1Dec mice

Show the 1 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:37963
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 5. Northern blot analysis on RNA derived from kidney of homozygous mice demonstrated that no detectable transcript is produced from this allele. Immunohistochemistry experiments on kidney sections from homozygous mice confirmed that no detectable protein is made. (J:37963)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Col4a3 Mutation:  9 strains or lines available
Original:  J:37963 Cosgrove D, et al., Collagen COL4A3 knockout: a mouse model for autosomal Alport syndrome. Genes Dev. 1996 Dec 1;10(23):2981-92
All:  41 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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