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Baxtm1Sjk
Targeted Allele Detail
Nomenclature
Symbol: Baxtm1Sjk
Name: BCL2-associated X protein; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:1857429
Synonyms: Bax-, Bax1
Gene: Bax  Location: Chr7:45461695-45466898 bp, - strand  Genetic Position: Chr7, 29.32 cM, cytoband B5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29253
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin selection cassette replaced exons 2 through 4 and part of exon 5, which encode sequences that correspond to the two BCL2 homology domains BH1 and BH2. Immunoblots did not detect the endcoded protein in tissue lysates derived from homozygous mice. (J:29253)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bax Mutation:  20 strains or lines available
References
Original:  J:29253 Knudson CM, et al., Bax-deficient mice with lymphoid hyperplasia and male germ cell death. Science. 1995 Oct 6;270(5233):96-9
All:  278 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory