Pou4f3^tm1Xia
Targeted Allele Detail

Summary

• Symbol: Pou4f3^tm1Xia
• Name: POU domain, class 4, transcription factor 3; targeted mutation 1, M Xiang
• MGI ID: MGI:1857425
• Synonyms: Brn-3c-
• Gene: Pou4f3 Location: Chr18:42527662-42529158 bp, + strand Genetic Position: Chr18, 22.58 cM, cytoband B3-E1
• Alliance: Pou4f3^tm1Xia page

Scanning electron microscopy of the organ of Corti in Pou4f3^tm1Xia/Pou4f3⁺ and Pou4f3^tm1Xia/Pou4f3^tm1Xia mice

Show the 5 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:42478
• Parent Cell Line: AB1 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A PGK neomycin cassette replaces the first exon and the majority of the second exon. This deletion encompasses most of the coding region for this gene. (J:42478)

Expression

In Mice Carrying this Mutation:	33 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou4f3 Mutation: 25 strains or lines available

References

• Original: J:42478 Xiang M, et al., Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997 Aug 19;94(17):9445-50
• All: 10 reference(s)