About   Help   FAQ
Fosbtm1Meg
Targeted Allele Detail
Nomenclature
Symbol: Fosbtm1Meg
Name: FBJ osteosarcoma oncogene B; targeted mutation 1, Michael E Greenburg
MGI ID: MGI:1857395
Synonyms: B-, FosB-
Gene: Fosb  Location: Chr7:19036621-19043970 bp, - strand  Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34461
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin selection cassette was inserted into exon 2, 5' to the sequences encoding the basic region and adjacent to the sequences encoding the transactivation domain. Northern blot analysis on RNA derived from serum-starved, stimulated embryonic fibroblasts derived from homozygous mice demonstrated that no detectable transcript is produced from this allele. Western blot analysis on these same cells confirmed that no detectable protein is encoded by this allele. (J:34461)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fosb Mutation:  15 strains or lines available
References
Original:  J:34461 Brown JR, et al., A defect in nurturing in mice lacking the immediate early gene fosB. Cell. 1996 Jul 26;86(2):297-309
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/16/2021
MGI 6.17
The Jackson Laboratory