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Targeted Allele Detail
Symbol: Fosbtm1Meg
Name: FBJ osteosarcoma oncogene B; targeted mutation 1, Michael E Greenburg
MGI ID: MGI:1857395
Synonyms: B-, FosB-
Gene: Fosb  Location: Chr7:19036621-19043970 bp, - strand  Genetic Position: Chr7, 9.56 cM, cytoband A2-B1
Germline Transmission:  Earliest citation of germline transmission: J:34461
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin selection cassette was inserted into exon 2, 5' to the sequences encoding the basic region and adjacent to the sequences encoding the transactivation domain. Northern blot analysis on RNA derived from serum-starved, stimulated embryonic fibroblasts derived from homozygous mice demonstrated that no detectable transcript is produced from this allele. Western blot analysis on these same cells confirmed that no detectable protein is encoded by this allele. (J:34461)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Fosb Mutation:  15 strains or lines available
Original:  J:34461 Brown JR, et al., A defect in nurturing in mice lacking the immediate early gene fosB. Cell. 1996 Jul 26;86(2):297-309
All:  12 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory