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Dsg3tm1Stan
Targeted Allele Detail
Nomenclature
Symbol: Dsg3tm1Stan
Name: desmoglein 3; targeted mutation 1, John R Stanley
MGI ID: MGI:1857388
Synonyms: Dsg3-
Gene: Dsg3  Location: Chr18:20510304-20541310 bp, + strand  Genetic Position: Chr18, 11.39 cM
Dsg3tm1Stan/Dsg3tm1Stan mice are runts and have skin erosions and eye lesions

Show the 6 image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:40804
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (knock-out)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Dsg3 Mutation:  13 strains or lines available
References
Original:  J:40804 Koch PJ, et al., Targeted disruption of the pemphigus vulgaris antigen (desmoglein 3) gene in mice causes loss of keratinocyte cell adhesion with a phenotype similar to pemphigus vulgaris. J Cell Biol. 1997 Jun 2;137(5):1091-102
All:  18 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory