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Sod2tm1Cje
Targeted Allele Detail
Nomenclature
Symbol: Sod2tm1Cje
Name: superoxide dismutase 2, mitochondrial; targeted mutation 1, Charles J Epstein
MGI ID: MGI:1857344
Synonyms: MnSOD, Sod2-, Sod2m1ucsf, Sod2mlucsf, Sod2tm1Bay
Gene: Sod2  Location: Chr17:13007839-13018119 bp, + strand  Genetic Position: Chr17, 8.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29899
Parent Cell Line:  CB1-4 (ES Cell)
Strain of Origin:  C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sod2 Mutation:  9 strains or lines available
Notes
Homozygous mutant mice die within 10 days after birth. They show dilated cardiomyopathy, lipid accumulation in skeletal muscles and in the liver, and acidosis. Succinate dehydrogenase and aconitase activities are severely reduced, especially in the heart. SOD2 is needed to protect mitochondrial enzymes susceptible to superoxide inactivation (J:29899).

References
Original:  J:29899 Li Y, et al., Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet. 1995 Dec;11(4):376-81
All:  62 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory