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Rw
Radiation induced Allele Detail
Nomenclature
Symbol: Rw
Name: rump white, inversion; rump white
MGI ID: MGI:1857317
Gene: Rw  Location: unknown  Genetic Position: Chr5, Syntenic
a/a Rw/Rw+

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Strain of Origin:  (C3H/HeH x 101/H)F1
Mutation
description
Allele Type:    Radiation induced
Mutation:    Inversion
  Rw involves 588 genes/genome features (B230308N11Rik, Gm15865, n-R5s171 ...) View all
 
Mutation detailsThis phenotypic allele has been attributed to In(5)6H, a 30 cM inversion in the proximal third of chromosome 5. The proximal breakpoint (In(5)6H-p) has been localized between codons 495 and 496 of Dpp6. Dpp6 mRNA was undetected in mutant mice by Northern blot analysis. Complementation analysis indicates that the recessive embryonic lethality attributed to the inversion results from a proximal region, and it had been suggested that the disrupted Dpp6 locus was responsible. However, additional deletions of the Dpp6 gene complement the rump white phenotype and these data suggest that Dpp6 is not required for viability. An additional locus, termed Qdpr is suggested to be the locus responsible for the lethal phenotype. (J:100332). The distal breakpoint (In(5)6H-d) has been localized between Pdgfra and Kit using FISH and pulsed field gel electrophoresis (PFGE). While the distal breakpoint does not disrupt the coding sequence of any known gene, it putatively has a long range effect on the expression of Kit, resulting in depigmentation of the scarolumbar region. (J:18646, J:19442, J:50926, J:100332)
Inheritance:    Semidominant
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 12 assay results
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Rw Mutation:  4 strains or lines available
References
Original:  J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory