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Targeted Allele Detail
Symbol: F2rtm1Ajc
Name: coagulation factor II (thrombin) receptor; targeted mutation 1, Andrew J Connolly
MGI ID: MGI:1857306
Synonyms: Par1-, Par1-, PAR-1-, tr-
Gene: F2r  Location: Chr13:95601789-95618433 bp, - strand  Genetic Position: Chr13, 50.21 cM
Germline Transmission:  Earliest citation of germline transmission: J:33380
Parent Cell Line:  RF8 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced sequences in exon 2 encoding transmembrane domains 1-7. Northern blot analysis on RNA derived from E12 embryos and from embryonic fibroblasts demonstrated that no detectable transcript was produced from this allele. Furthermore, transcripts from this allele were not detected in various tissues of adult homozygous mice (data not shown). (J:33380)
View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any F2r Mutation:  10 strains or lines available
Original:  J:33380 Connolly AJ, et al., Role of the thrombin receptor in development and evidence for a second receptor. Nature. 1996 Jun 6;381(6582):516-9
All:  44 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.03
The Jackson Laboratory