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Targeted Allele Detail
Symbol: Icam1tm1Jcgr
Name: intercellular adhesion molecule 1; targeted mutation 1, Jose Carlos Gutierrez Ramos
MGI ID: MGI:1857292
Synonyms: ICAM-1-, ICAM-1-deficient, ICAMtm1-jcgr
Gene: Icam1  Location: Chr9:21015985-21028817 bp, + strand  Genetic Position: Chr9, 7.69 cM
Germline Transmission:  Earliest citation of germline transmission: J:18743
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 4 of the gene. While King, et. al. (J:25530) reported the potential for the production of functional proteins arising from alternative transcripts, corresponding signals were undetected by immunohistochemical analysis of homozygous mutant mice. (J:18743)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Icam1 Mutation:  17 strains or lines available
Original:  J:18743 Xu H, et al., Leukocytosis and resistance to septic shock in intercellular adhesion molecule 1-deficient mice. J Exp Med. 1994 Jul 1;180(1):95-109
All:  81 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory