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Targeted Allele Detail
Symbol: Plattm1Mlg
Name: plasminogen activator, tissue; targeted mutation 1, Richard C Mulligan
MGI ID: MGI:1857288
Synonyms: Plattm1, t-PA-, tPA-
Gene: Plat  Location: Chr8:23247743-23272860 bp, + strand  Genetic Position: Chr8, 11.42 cM
Germline Transmission:  Earliest citation of germline transmission: J:17427
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe gene was disrupted using neomycin resistance cassette. The vector replaced genomic sequences encoding most of the kringle-2 domain and part of the proteinase domain, including the catalytically essential histidine residue at position 326. Targeting was confirmed by the absence of gene specific mRNA and immunoreactivity. (J:17427)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Plat Mutation:  26 strains or lines available
Original:  J:17427 Carmeliet P, et al., Physiological consequences of loss of plasminogen activator gene function in mice. Nature. 1994 Mar 31;368(6470):419-24
All:  153 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.21
The Jackson Laboratory