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Atf2tm1Glm
Targeted Allele Detail
Nomenclature
Symbol: Atf2tm1Glm
Name: activating transcription factor 2; targeted mutation 1, Laurie Glimcher
MGI ID: MGI:1857283
Synonyms: ATF-2 -, ATF-2m
Gene: Atf2  Location: Chr2:73816509-73892639 bp, - strand  Genetic Position: Chr2, 43.86 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:30611
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsA neomycin cassette was inserted into sequences corresponding to position 899 of the encoded mRNA (in the exon encoding amino acids 277-326). Although no full length protein is observed, these mice are hypomorphic as they express low levels of a novel spliced protein. (J:30611, J:55657)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 4 assay results
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Atf2 Mutation:  46 strains or lines available
References
Original:  J:30611 Reimold AM, et al., Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature. 1996 Jan 18;379(6562):262-5
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory