Atf2^tm1Glm
Targeted Allele Detail

Summary

• Symbol: Atf2^tm1Glm
• Name: activating transcription factor 2; targeted mutation 1, Laurie Glimcher
• MGI ID: MGI:1857283
• Synonyms: ATF-2 -, ATF-2^m
• Gene: Atf2 Location: Chr2:73646853-73722983 bp, - strand Genetic Position: Chr2, 43.86 cM
• Alliance: Atf2^tm1Glm page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:30611
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Hypomorph)
• Mutation: Insertion
• Mutation details: A neomycin cassette was inserted into sequences corresponding to position 899 of the encoded mRNA (in the exon encoding amino acids 277-326). Although no full length protein is observed, these mice are hypomorphic as they express low levels of a novel spliced protein. (J:30611, J:55657)

Disease models

Expression

In Mice Carrying this Mutation:	6 assay results
In Structures Affected by this Mutation:	12 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Atf2 Mutation: 89 strains or lines available

References

• Original: J:30611 Reimold AM, et al., Chondrodysplasia and neurological abnormalities in ATF-2-deficient mice. Nature. 1996 Jan 18;379(6562):262-5
• All: 8 reference(s)