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Targeted Allele Detail
Symbol: Vldlrtm1Her
Name: very low density lipoprotein receptor; targeted mutation 1, Joachim Herz
MGI ID: MGI:1857267
Synonyms: VLDLR-
Gene: Vldlr  Location: Chr19:27193884-27231631 bp, + strand  Genetic Position: Chr19, 21.77 cM
Germline Transmission:  Earliest citation of germline transmission: J:28591
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe insertion of a neomycin selection cassette into exon 5 deleted a portion of the coding sequence and disrupted the reading frame. Immunoblot analysis of heart muscle membranes did not detect protein in homozygous mutant animals. (J:28591)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 13 assay results
In Structures Affected by this Mutation: 14 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vldlr Mutation:  47 strains or lines available
Original:  J:28591 Frykman PK, et al., Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8453-7
All:  96 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory