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Vldlrtm1Her
Targeted Allele Detail
Summary
Symbol: Vldlrtm1Her
Name: very low density lipoprotein receptor; targeted mutation 1, Joachim Herz
MGI ID: MGI:1857267
Synonyms: VLDLR-
Gene: Vldlr  Location: Chr19:27193884-27231631 bp, + strand  Genetic Position: Chr19, 21.77 cM
Alliance: Vldlrtm1Her page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:28591
Parent Cell Line:  JH1 (ES Cell)
Strain of Origin:  129S7/SvEvBrd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe insertion of a neomycin selection cassette into exon 5 deleted a portion of the coding sequence and disrupted the reading frame. Immunoblot analysis of heart muscle membranes did not detect protein in homozygous mutant animals. (J:28591)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 20 assay results
3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation: 14 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Vldlr Mutation:  69 strains or lines available
References
Original:  J:28591 Frykman PK, et al., Normal plasma lipoproteins and fertility in gene-targeted mice homozygous for a disruption in the gene encoding very low density lipoprotein receptor. Proc Natl Acad Sci U S A. 1995 Aug 29;92(18):8453-7
All:  105 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory