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Targeted Allele Detail
Symbol: Ttrtm1Wsb
Name: transthyretin; targeted mutation 1, William S Blaner
MGI ID: MGI:1857264
Synonyms: ttr-, TTR KO
Gene: Ttr  Location: Chr18:20665280-20674321 bp, + strand  Genetic Position: Chr18, 11.47 cM
Germline Transmission:  Earliest citation of germline transmission: J:4183
Parent Cell Line:  CCE/EK.CCE (ES Cell)
Strain of Origin:  129S/SvEv-Gpi1c
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsInsertion of a neomycin resistance cassette into the second exon disrupted the gene. Western blot analysis of peripheral blood using a rat polyclonal antiserum did not detect protein in homozygous mutant mice. (J:4183)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ttr Mutation:  36 strains or lines available
Original:  J:4183 Episkopou V, et al., Disruption of the transthyretin gene results in mice with depressed levels of plasma retinol and thyroid hormone. Proc Natl Acad Sci U S A. 1993 Mar 15;90(6):2375-9
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory