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Tlx1tm1Sjk
Targeted Allele Detail
Nomenclature
Symbol: Tlx1tm1Sjk
Name: T cell leukemia, homeobox 1; targeted mutation 1, Stanley J Korsmeyer
MGI ID: MGI:1857260
Synonyms: Hox11-, Tlx-, Tlx1-
Gene: Tlx1  Location: Chr19:45150680-45156943 bp, + strand  Genetic Position: Chr19, 38.45 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17695
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 1 was disrupted by the insertion of a neomycin selection cassette into codon 53. Transcript was undetected by in situ hybridization of homozygous mutant mice. (J:17695)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 9 assay results
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tlx1 Mutation:  13 strains or lines available
References
Original:  J:17695 Roberts CW, et al., Hox11 controls the genesis of the spleen. Nature. 1994 Apr 21;368(6473):747-9
All:  14 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory