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Targeted Allele Detail
Symbol: Tgfb3tm1Doe
Name: transforming growth factor, beta 3; targeted mutation 1, Thomas Doetschman
MGI ID: MGI:1857259
Synonyms: TGF-beta3 null
Gene: Tgfb3  Location: Chr12:86103519-86125815 bp, - strand  Genetic Position: Chr12, 40.09 cM
Germline Transmission:  Earliest citation of germline transmission: J:29901
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin resistance cassette replaced exon 6, which encodes the active domain of the protein. RT-PCR analysis of RNA derived from whole E11.5 or E15.5 embryos did not detect any transcript produced from this allele in homozygous mice. (J:29901)
View phenotypes and curated references for all genotypes (concatenated display).
In Mice Carrying this Mutation: 73 assay results
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tgfb3 Mutation:  28 strains or lines available
Original:  J:29901 Proetzel G, et al., Transforming growth factor-beta 3 is required for secondary palate fusion. Nat Genet. 1995 Dec;11(4):409-14
All:  38 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.17
The Jackson Laboratory