Tgfb1^tm1Doe
Targeted Allele Detail

Summary

• Symbol: Tgfb1^tm1Doe
• Name: transforming growth factor, beta 1; targeted mutation 1, Thomas Doetschman
• MGI ID: MGI:1857258
• Synonyms: Tgfb1^-, TGFbeta1
• Gene: Tgfb1 Location: Chr7:25386427-25404502 bp, + strand Genetic Position: Chr7, 13.98 cM
• Alliance: Tgfb1^tm1Doe page

Lung and salivary gland inflammation in Tgfb1^tm2.1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (b,e) and Tgfb1^tm1Doe/Tgfb1^tm2.1Doe Tg(Lck-cre)548Jxm/? (c,f) mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:2892
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A neomycin resistance cassette was inserted into exon 6 of the gene, disrupting the production of a mature peptide. (J:2892)

Disease models

Expression

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	18 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Tgfb1^tm1Doe

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any Tgfb1 Mutation: 34 strains or lines available

References

• Original: J:2892 Shull MM, et al., Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 1992 Oct 22;359(6397):693-9
• All: 67 reference(s)