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Tcrbtm1Mom
Targeted Allele Detail
Nomenclature
Symbol: Tcrbtm1Mom
Name: T cell receptor beta chain; targeted mutation 1, Peter Mombaerts
MGI ID: MGI:1857256
Synonyms: beta-, CBeta-, TCRb-, TCRbeta-, TCR-Cbeta-
Gene: Tcrb  Location: unknown  Genetic Position: Chr6, cytoband A-C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:22591
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details15kb of sequence was replaced with a PGK-neo cassette. The deletion included one of the two D gene segments, ten of the twelve J gene segments, and both constant gene segments. (J:22591)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 12 strains available      Cell Lines: 0 lines available
Carrying any Tcrb Mutation:  87 strains or lines available
References
Original:  J:22591 Mombaerts P, et al., Creation of a large genomic deletion at the T-cell antigen receptor beta-subunit locus in mouse embryonic stem cells by gene targeting. Proc Natl Acad Sci U S A. 1991 Apr 15;88(8):3084-7
All:  410 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory