About   Help   FAQ
Tal1tm1Sho
Targeted Allele Detail
Nomenclature
Symbol: Tal1tm1Sho
Name: T cell acute lymphocytic leukemia 1; targeted mutation 1, Stuart Orkin
MGI ID: MGI:1857254
Synonyms: SCL, tal-1-
Gene: Tal1  Location: Chr4:115056426-115071755 bp, + strand  Genetic Position: Chr4, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:23061
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsReplacement of coding sequences of the Tal1 gene, including the bHLH sequences, with a neomycin cassette. (J:23061)
Inheritance:    Recessive
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 8 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Tal1 Mutation:  16 strains or lines available
References
Original:  J:23061 Shivdasani RA, et al., Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL. Nature. 1995 Feb 2;373(6513):432-4
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory