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Stat4tm1Gru
Targeted Allele Detail
Nomenclature
Symbol: Stat4tm1Gru
Name: signal transducer and activator of transcription 4; targeted mutation 1, Michael J Grusby
MGI ID: MGI:1857248
Synonyms: Stat4-
Gene: Stat4  Location: Chr1:52026307-52146348 bp, + strand  Genetic Position: Chr1, 26.67 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:34059
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsThe exon encoding amino acids 263 through 314 was disrupted by the insertion of a neomycin selection cassette. The encoded protein was undetectable in the thymi and lymph nodes of homozygous mutant mice by immunoblot analysis. (J:34059)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Stat4 Mutation:  46 strains or lines available
References
Original:  J:34059 Kaplan MH, et al., Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature. 1996 Jul 11;382(6587):174-7
All:  178 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/23/2021
MGI 6.17
The Jackson Laboratory