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Targeted Allele Detail
Symbol: Ccl3tm1Unc
Name: chemokine (C-C motif) ligand 3; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857243
Synonyms: MIP-1alpha -, Scya3 -, Scya3tm1Coo
Gene: Ccl3  Location: Chr11:83647844-83649355 bp, - strand  Genetic Position: Chr11, 51.04 cM
Hexbtm1Rlp/Hexbtm1Rlp mice exhibit Sandhoff disease phenotypes that are improved in Hexbtm1Rlp/Hexbtm1Rlp Ccl3tm1Unc/Ccl3tm1Unc mice

Show the 3 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:28704
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA neomycin selection cassette was used to delete a region including 300 nucleotides of the 5' untranslated region, all of exon 1, and a portion of exon 2. An absence of transcript was observed via Northern blot analysis of total mRNA derived from bone marrow macrophages isolated from homozygous mutant animals. (J:28704)
View phenotypes for all genotypes (concatenated display).
Disease models
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ccl3 Mutation:  2 strains or lines available
Original:  J:28704 Cook DN, et al., Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science. 1995 Sep 15;269(5230):1583-5
All:  62 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.01
The Jackson Laboratory