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Prf1tm1Sdz
Targeted Allele Detail
Nomenclature
Symbol: Prf1tm1Sdz
Name: perforin 1 (pore forming protein); targeted mutation 1, Sandoz Pharmaceuticals
MGI ID: MGI:1857235
Synonyms: P0, perf-, perforin-, perforin 0, Pfn-, pfp-, pfpKO, Pfptm1Sdz, pko, Prf-, Prf1-, prf1tm1, Prf1tm/Sdz
Gene: Prf1  Location: Chr10:61297836-61304263 bp, + strand  Genetic Position: Chr10, 32.18 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:17986
Parent Cell Line:  BL/6-III (ES Cell)
Strain of Origin:  C57BL/6J
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation details
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Prf1 Mutation:  9 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: hemophagocytic lymphohistiocytosis in mutants infected with lymphocytic choriomeningitic virus (J:92260)

References
Original:  J:17986 Kagi D, et al., Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice [see comments]. Nature. 1994 May 5;369(6475):31-7
All:  239 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory