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Nppatm1Unc
Targeted Allele Detail
Nomenclature
Symbol: Nppatm1Unc
Name: natriuretic peptide type A; targeted mutation 1, University of North Carolina
MGI ID: MGI:1857231
Synonyms: ANP-, proANP-
Gene: Nppa  Location: Chr4:148000722-148002079 bp, + strand  Genetic Position: Chr4, 78.66 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:76312
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation details11 bp of exon 2 was replaced with a neomycin resistance gene via homologous recombination. Radioimmunoassay of plasma and atria from homozygous mutant animals did not detect protein product. (J:76312)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nppa Mutation:  4 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Salt-Sensitive Hypertension (J:76312).
References
Original:  J:76312 John SW, et al., Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science. 1995 Feb 3;267(5198):679-81
All:  25 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory