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Nos2tm1Lau
Targeted Allele Detail
Nomenclature
Symbol: Nos2tm1Lau
Name: nitric oxide synthase 2, inducible; targeted mutation 1, Victor E Laubach
MGI ID: MGI:1857228
Synonyms: iNOS-, iNOS-, iNOS KO, NOS2-, Nos2tm1Lau, NOS2tm/Lau
Gene: Nos2  Location: Chr11:78920787-78960254 bp, + strand  Genetic Position: Chr11, 46.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:29677
Parent Cell Line:  E14TG2a (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin cassette replaced exons 12 and 13 of the gene, which encode the calmodulin-binding domain. Northern and Western blots of IFNg/LPS-stimulated peritoneal macrophages showed no detectable Nos2 mRNA or protein, respectively. (J:29677, J:183641)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 23 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 7 strains available      Cell Lines: 0 lines available
Carrying any Nos2 Mutation:  32 strains or lines available
References
Original:  J:29677 Laubach VE, et al., Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proc Natl Acad Sci U S A. 1995 Nov 7;92(23):10688-92
All:  405 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/10/2018
MGI 6.12
The Jackson Laboratory