Nfe2^tm1Sho
Targeted Allele Detail

Summary

• Symbol: Nfe2^tm1Sho
• Name: nuclear factor, erythroid derived 2; targeted mutation 1, Stuart Orkin
• MGI ID: MGI:1857224
• Synonyms: NF-E2-, p45^NFE2-, p45 NF-E2-
• Gene: Nfe2 Location: Chr15:103156640-103166809 bp, - strand Genetic Position: Chr15, 58.62 cM
• Alliance: Nfe2^tm1Sho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:20132
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A PGK-neomycin cassette was inserted into exon 3, immediately upstream of sequences required for DNA binding and protein dimerization. Absence of intact mRNA and protein were demonstrated by Northern and immunoblot analyses, respectively. (J:20132)

Expression

In Mice Carrying this Mutation:	8 assay results
In Structures Affected by this Mutation:	6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfe2 Mutation: 20 strains or lines available

References

• Original: J:20132 Shivdasani RA, et al., Transcription factor NF-E2 is required for platelet formation independent of the actions of thrombopoietin/MGDF in megakaryocyte development. Cell. 1995 Jun 2;81(5):695-704
• All: 33 reference(s)