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Ncam1tm1Cgn
Targeted Allele Detail
Nomenclature
Symbol: Ncam1tm1Cgn
Name: neural cell adhesion molecule 1; targeted mutation 1, University of Cologne
MGI ID: MGI:1857222
Synonyms: Ncam-, N-CAM-, NCAM-, N-CAM-1-
Gene: Ncam1  Location: Chr9:49502136-49798925 bp, - strand  Genetic Position: Chr9, 26.83 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:16590
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced most of exons 3 and 4 and the intervening intron. Ribonuclease protection assays did not detect wild-type or read-through transcripts or alternative or cryptic splicing in brain tissue from homozygous mutant mice. Western blot analysis of brain tissue using a monoclonal antibody or a polyclonal rabbit serum did not detect protein in homozygous mutant mice. Similarly, immunostaining did not detect protein in mutant olfactory bulb. (J:16590)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 9 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ncam1 Mutation:  41 strains or lines available
References
Original:  J:16590 Cremer H, et al., Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning. Nature. 1994 Feb 3;367(6462):455-9
All:  78 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory