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Myod1tm1Jae
Targeted Allele Detail
Nomenclature
Symbol: Myod1tm1Jae
Name: myogenic differentiation 1; targeted mutation 1, Rudolf Jaenisch
MGI ID: MGI:1857221
Synonyms: MyoD (-), MyoD-, MyoDml
Gene: Myod1  Location: Chr7:46376474-46379092 bp, + strand  Genetic Position: Chr7, 30.03 cM
Dmdmdx/? Myod1tm1Jae/Myod1tm1Jae mice develop cardiomyopathy

Show the 2 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:3070
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Replacement of the MyoD promoter, exon 1 and half of intron 1 with a neomycin cassette. (J:3070)
Phenotypes
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Disease models
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Expression
In Mice Carrying this Mutation: 119 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Myod1 Mutation:  5 strains or lines available
References
Original:  J:3070 Rudnicki MA, et al., Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell. 1992 Oct 30;71(3):383-90
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory