Myod1^tm1Jae
Targeted Allele Detail

Summary

• Symbol: Myod1^tm1Jae
• Name: myogenic differentiation 1; targeted mutation 1, Rudolf Jaenisch
• MGI ID: MGI:1857221
• Synonyms: MyoD (-), MyoD-, MyoD^ml
• Gene: Myod1 Location: Chr7:46025898-46028516 bp, + strand Genetic Position: Chr7, 30.03 cM
• Alliance: Myod1^tm1Jae page

Dmd^mdx/? Myod1^tm1Jae/Myod1^tm1Jae mice develop cardiomyopathy

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3070
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Replacement of the MyoD promoter, exon 1 and half of intron 1 with a neomycin cassette. (J:3070)

Disease models

Expression

In Mice Carrying this Mutation:

355 assay results 1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Myod1 Mutation: 23 strains or lines available

References

• Original: J:3070 Rudnicki MA, et al., Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Cell. 1992 Oct 30;71(3):383-90
• All: 82 reference(s)